FTO基因
腰围
肥胖
内科学
医学
体质指数
C反应蛋白
内分泌学
脂肪组织
基因型
超重
生物
单核苷酸多态性
等位基因
基因
优势比
多态性(计算机科学)
人口
作者
Yanlei Sun,Jiazhong Sun,Xiang Wang,Wei You,Mei Yang
出处
期刊:Clinical and Investigative Medicine
日期:2010-12-01
卷期号:33 (6): 405-412
被引量:15
标识
DOI:10.25011/cim.v33i6.14592
摘要
Purpose: Various genetic variants of the fat mass and obesity associated gene (FTO) have been linked to obesity in populations of Europeans. Low-grade inflammation is a key feature of obesity, characterized by elevated plasma levels of C-reactive protein (CRP). In the present study, we have investigated whether the FTO-risk variant is associated with obesity and CRP in the Chinese population.
Methods: 1799 individuals aged 50-70 years (896 men and 903 women), including both obese (560 cases) and control individuals, (1200 cases) were recruited. The FTO rs9939609 polymorphism was tested using sequences retrieval. Waist circumference, body fat, hs-CRP, blood total cholesterol, triglycerides and LDL-C were also measured.
Results: The FTO rs9939609 polymorphism per-A allele was associated with an increased odds ratio for obesity of 1.42 (95%CI 1.23-1.64). The genotypic odds ratio for obesity was 1.92 (95%CI 1.43-2.57) for the AA genotype, 1.71 (95%CI 1.35-2.16) for the AT genotype. The association between FTO rs9939609 polymorphism and CRP levels was r=0.78.
Conclusion: Our data support the hypothesis that FTO rs9939609 polymorphism is strongly associated with obesity and CRP levels in the Chinese population as reported in the European population.
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