壳聚糖
右旋糖酐
间充质干细胞
生物相容性
心肌梗塞
自愈水凝胶
活力测定
化学
细胞疗法
脐带
细胞
药理学
生物医学工程
医学
免疫学
生物化学
内科学
病理
有机化学
作者
Ke Xiao,Mingyan Li,Xiaoqing Wang,Jiawen Liang,Xing Wang,Duen‐Yau Chuang,Ming Long,Chengheng Hu
标识
DOI:10.1016/j.carbpol.2019.115516
摘要
Acute myocardial infarction (MI) is a common cardiovascular disease with high mortality. In this study, an injectable thermosensitive hydrogel of chitosan (CS)/dextran (DEX)/β-glycerophosphate (β-GP) loaded with umbilical cord mesenchymal stem cells (UCMSCs) was prepared for MI treatment. The good biocompatibility of hydrogels was confirmed by 3T3 cells and HUVECs culture study in vitro. HUVECs encapsulated in the hydrogels showed a cell delivery ability. Furthermore, the results indicated that hydrogel could encapsulate most of UCMSCs and the cells exhibited good viability in CS/ 1.0DEX/β-GP hydrogels. The expression of cardiac markers of cTnI and Cx43 and signaling pathways of p-Akt and p-ERK1/2 were studied, and it showed that UCMSCs differentiate towards myocardium and has a great potential for therapeutic use of cardiac repair. In conclusion, the thermosensitive hydrogel of CS/1.0 DEX/β-GP loaded UCMSCs was a promising candidate as cell delivery vehicle for cardiac repair to reconstitute damaged myocardium.
科研通智能强力驱动
Strongly Powered by AbleSci AI