A Review on the Synthetic Routes to β-Keto Amides

This review summarizes the data published on the methods of preparation of β- keto amides as a versatile synthon for many heterocyclic rings and asymmetric urea derivatives. Based on the starting materials used for the synthesis of β-keto amides, eight methods were reported including β-keto acids and their derivatives, Meldrum’s acid and their derivatives, diketene, 2,6-dimethyl-1,3-dioxin-4-one derivatives (TMD), α-diazo ketones, enamines and enolates, acetamides and their derivatives and reduction of certain Passerini products.