画笔边框
肾
化学
共价键
放射化学
抗体
肾脏生理学
生物化学
膜
内科学
医学
免疫学
有机化学
小泡
标识
DOI:10.1016/j.nucmedbio.2020.03.001
摘要
The high and persistent radioactivity levels in the kidney constitute a long-unsettled problem of radiolabeled peptides and low molecular weight (LMW) polypeptides, especially when they are labeled with metallic radionuclides. To address the issue, we proposed an approach to liberate a radiometabolite of urinary excretion from covalently conjugated antibody Fab fragments, used as a representative LMW polypeptide, by the action of enzymes present on the brush border membrane of renal tubules. In this review, The history of our approach, starting from radioiodine to metallic radionuclides such as 188Re, 99mTc, 67/68Ga, and 111In, will be briefly described. The future perspective of this approach will also be described.
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