医学
内科学
糖尿病
心脏病学
亚临床感染
入射(几何)
年轻人
钙化
人口统计学的
动脉
冠状动脉钙
冠状动脉疾病
内分泌学
人口学
社会学
物理
光学
作者
Weijing Feng,Zhibin Li,Weichao Guo,Xianglin Fan,Feiran Zhou,Kun Zhang,Caiwen Ou,Feifei Huang,Minsheng Chen
出处
期刊:Diabetes Care
[American Diabetes Association]
日期:2020-07-30
卷期号:43 (10): 2574-2580
被引量:11
摘要
OBJECTIVE To investigate whether intraindividual variability of fasting glucose (FG) in young adulthood is associated with coronary artery calcification (CAC) progression in middle age. RESEARCH DESIGN AND METHODS We included 2,256 CARDIA (Coronary Artery Risk Development Study in Young Adults) participants with CAC assessment by computed tomography scanner at baseline (2000–2001) and 10 years later (2010–2011). CAC progression was assessed for each individual as the difference of logarithmic CAC scores at follow-up and baseline (log[CAC (follow-up) + 1] − log[CAC (baseline) + 1]). FG variability was defined by the coefficient of variation about the mean FG (FG-CV), the SD of FG (FG-SD), and the average real variability of FG (FG-ARV) during the 10-year follow-up. We investigated the association between FG variability and CAC progression with adjustment for demographics, clinical risk factors, mean FG level, change in FG level, diabetes incidence, and medication use. RESULTS After multivariable adjustment, 1-SD increment in FG-CV was associated with worse progression of CAC as demonstrated as percent change in CAC, with incident CAC 5.9% (95% CI 1.0, 10.7) and any CAC progression 6.7% (95% CI 2.3, 11.1) during 10 years. Similar findings were also observed in FG-SD and FG-ARV. CONCLUSIONS Higher FG variability during young adulthood was associated with greater CAC progression in middle age, suggesting its value in predicting risk for subclinical coronary artery diseases.
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