骨形态发生蛋白
脱钙骨基质
骨形态发生蛋白7
骨形态发生蛋白2
骨移植
脊柱融合术
医学
骨愈合
基质骨
骨形态发生蛋白5
细胞生物学
生物
解剖
外科
材料科学
数据库管理
软骨
体外
遗传学
基因
放大器
光电子学
CMOS芯片
作者
T. Kuber Sampath,A. Hari Reddi
出处
期刊:Bone
[Elsevier]
日期:2020-11-01
卷期号:140: 115548-115548
被引量:47
标识
DOI:10.1016/j.bone.2020.115548
摘要
Bone morphogenetic proteins (BMPs) were purified from demineralized bone matrix by their ability to induce new bone formation in vivo. BMPs represent a large sub-family of proteins structurally related to TGF-beta and activins. Two BMP bone graft substitutes, BMP2 (InFuse®) and BMP7 (OP1®) have been developed as products for the repair of long bone non-union fractures and lumbar spinal fusion in humans. The approval of BMP2 and BMP7 based products for use in the clinic supports that the signals responsible for bone formation at ectopic sites can form a basis as therapeutics for bone repair and regeneration. This article describes a historical perspective of the discovery BMPs.
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