Cover Feature: Synthesis of 2-Substituted 1,2,3-Triazoles via an Intramolecular N -N Bond Formation (Eur. J. Org. Chem. 5/2020)

The Cover Feature shows how the in-situ generated hydrazonium species leads to the formation of a wide variety of 2-aryl-1,2,3-triazoles under very mild conditions. A preliminary computational DFT study on the reaction pathway suggest that the reaction likely follows an intramolecular SN2 displacement mechanism with the trimethyl-ammonium moiety serving as a good leaving group for the intramolecular N-N bond formation. More information can be found in the Communication by C.-y. Chen et al.