DNA甲基化
生物
重编程
甲基化
DNA
遗传学
脱甲基酶
RNA导向的DNA甲基化
拟南芥
表观遗传学
功能(生物学)
基因组
计算生物学
基因
基因表达
突变体
作者
Daniel Grimanelli,Mathieu Ingouff
标识
DOI:10.1016/j.jmb.2019.12.043
摘要
In plants, DNA methylation occurs in distinct sequence contexts, including CG, CHG, and CHH. Thus, plants have developed a surprisingly diverse set of DNA methylation readers to cope with an extended repertoire of methylated sites. The Arabidopsis genome contains twelve Methyl-Binding Domain proteins (MBD), and nine SET and RING finger-associated (SRA) domain containing proteins belonging to the SUVH clade, in addition to three homologs of UHRF1, namely VIM1-3, all containing SRA domains. In this review, we will highlight several research questions that remain unresolved with respect to the function of plant DNA methylation readers, which can have both de novo demethylase and maintenance activity. We argue that maintenance of CG methylation in plants likely involved actors not found in their mammalian counterparts, and that new evidence suggests significant reprogramming of DNA methylation during plant reproduction as an important new development in the field.
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