Relationship Between Final Visual Acuity and Optical Coherence Tomography Findings in Patients with Diabetic Macular Edema Undergoing Anti-VEGF Therapy

光学相干层析成像 糖尿病性黄斑水肿 医学 眼科 视力 血管内皮生长因子受体 黄斑水肿 水肿 糖尿病性视网膜病变 糖尿病 外科 内科学 内分泌学
作者
Seher Eraslan,Özlem Yıldırım,Özer Dursun,Erdem Dinç,Gülhan Örekici Temel
出处
期刊:Türk Oftalmoloji Dergisi [Galenos Yayinevi]
卷期号:50 (3): 163-168 被引量:12
标识
DOI:10.4274/tjo.galenos.2019.91962
摘要

Objectives: To identify the prevalence of findings in optical coherence tomography (OCT) sections before intravitreal anti-VEGF treatment in patients with diabetic macular edema (DME), and to evaluate the relationship between these findings and final visual acuity and number of injections.Materials and Methods: This retrospective study included 296 eyes of 191 patients (104 male, 87 female) who started intravitreal ranibizumab treatment after being diagnosed with DME in the retina unit between January 2013 and April 2017 were included the study.Spectral domain OCT findings at the time of presentation such as presence of serous macular detachment (SD), vitreomacular traction (VMT), and epiretinal membrane (ERM) were recorded.In addition, the regularity of the ellipsoid zone (EZ) and inner retinal layers was also studied. Results:The mean central retinal thickness measured in SD-OCT was 449±81 μm before treatment and 350±96 μm after treatment (p<0.001).SD was detected in 155 eyes (52.4%),ERM in 67 eyes (22.6%), and VMT in 9 eyes (3%).Thirty eyes (10.1%) had disorganization of the retinal inner layers (DRIL) and 54 eyes (18.2%) had EZ deterioration.The presence of ERM, EZ irregularity, and DRIL were associated with significantly lower final visual acuity (p<0.0001), while there was no relationship between pre-treatment SD and final visual acuity (p=0.11).Injection number was higher in eyes with SD and ERM compared to those without, but this difference was statistically significant only in the presence of SD (p=0.01 and p=0.59, respectively).There was no difference in injection number according to EZ irregularity or presence of DRIL. Conclusion:The coexistence of SD with DME was associated with increased need for treatment but not with final visual acuity.EZ irregularities, DRIL, and ERM are findings that negatively affect visual acuity.
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