重编程
免疫疗法
抑制性突触后电位
癌症免疫疗法
细胞生物学
过继性细胞移植
癌细胞
癌症
癌症研究
全身给药
心理压抑
神经科学
基因
生物
免疫学
T细胞
免疫系统
基因表达
遗传学
体内
作者
Iñaki Etxeberría,Irene Olivera,Elixabet Bolaños,Asunta Cirella,Álvaro Teijeira,Pedro Berraondo,Ignacio Melero
标识
DOI:10.1038/s41423-020-0464-1
摘要
Gene engineering and combinatorial approaches with other cancer immunotherapy agents may confer capabilities enabling full tumor rejection by adoptive T cell therapy (ACT). The provision of proper costimulatory receptor activity and cytokine stimuli, along with the repression of inhibitory mechanisms, will conceivably make the most of these treatment strategies. In this sense, T cells can be genetically manipulated to become refractory to suppressive mechanisms and exhaustion, last longer and differentiate into memory T cells while endowed with the ability to traffic to malignant tissues. Their antitumor effects can be dramatically augmented with permanent or transient gene transfer maneuvers to express or delete/repress genes. A combination of such interventions seeks the creation of the ultimate bionic T cell, perfected to seek and destroy cancer cells upon systemic or local intratumor delivery.
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