Influencing factors and interpretation of the clinical laboratory assay result of acute kidney injury

More and more laboratory indicators including serum creatinine, serum cystatin C, urinary microalbumin, N-acetyl- beta- D- Glucosaminidase (NAG), kidney injury molecule 1 (KIM-1), neutrophil gelatinase- associated lipocalin (NGAL), interleukin 18 (IL-18) and L type fatty acid binding protein (L-FABP) are used to diagnose and monitor acute kidney injury (AKI). However, the clinical applicability and limitations of these indicators, as well as the detection effect factors and biological variation on the diagnosis and monitoring of AKI are very important, especially how to combine the detection effect factors and biological variation to interpret test result is attached great importance by the laboratory personnel.(Chin J Lab Med, 2016, 39: 879-884) Key words: Acute kidney injury; Creatinine; Cystatin C