克洛丹
医学
胃
转移
紧密连接
食管胃交界处
淋巴结
内科学
胃肠病学
淋巴结转移
原发性肿瘤
腺癌
肿瘤科
病理
癌症
癌症研究
生物
细胞生物学
作者
Alexander Arnold,S Daum,Moritz von Winterfeld,Erika Gebel Berg,Michael Hummel,Beate Rau,Ulrike Stein,Christoph Treese
标识
DOI:10.1007/s12094-020-02380-0
摘要
Abstract Introduction The tight junction molecule Claudin 18.2 is selectively expressed in healthy and malignant gastric epithelial tissue and is a promising therapy target for high Claudin 18.2 expressing adenocarcinomas of the esophagogastric junction and stomach (AEG/S). Methods This study analyzed the prevalence, characteristics and prognostic impact of Claudin 18.2 expression in primary tumor, lymph node and distant metastasis in a large Caucasian AGE/S cohort with 414 patients. Results Claudin 18.2 was highly expressed in 17.1% of primary tumors, 26.7% of lymph node metastasis and 16.7% of distant metastasis. High Claudin 18.2 expression in lymph node metastasis and primary tumors correlated significantly ( p < 0.001). High expression of Claudin 18.2 was neither associated with histomorphogical subtype, or tumor state, nor with overall survival. Conclusion In Caucasian AEG/S patients, 17.1% appeared to be eligible for an anti-Claudin 18.2 therapy. Claudin 18.2 expression itself has no impact on prognosis and is not related to any tumor subtype.
科研通智能强力驱动
Strongly Powered by AbleSci AI