弱点
危重病多发性神经病
医学
肌肉无力
重症监护医学
败血症
肌膜
神经肌肉接头
机械通风
肌病
机制(生物学)
病危
内科学
物理医学与康复
麻醉
神经科学
危重病
外科
骨骼肌
心理学
哲学
认识论
出处
期刊:International Journal of Anesthesiology and Resuscitation
[Chinese Medical Association]
日期:2019-05-15
卷期号:40 (5): 471-474
标识
DOI:10.3760/cma.j.issn.1673-4378.2019.05.012
摘要
Sepsis can cause changes of nerve, sarcolemma, neuromuscular junction (NMJ) and excitation-contraction coupling for promoting the acquired muscle weakness. Acquired weakness of muscles can prolong the time of mechanical ventilation and hospital stay of patients. It is an independent risk factor leading to the increase of mortality in critically ill patients and seriously affects the patients′ quality of life. In this paper, the research progress of the mechanism of sepsis-induced acquired weakness in recent years is reviewed so as to provide theoretical basis for clinical work. Although the mechanism of sepsis-induced acquired weakness is not fully understood at present, further research will lay a solid theoretical foundation for clinical diagnosis, treatment and anesthesia.
Key words:
Sepsis; Acquired weakness of muscles; Neuromuscular dysfunction; Critical illness polyneuropathy; Critical illness myopathy
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