适体
变构调节
化学
DNA
DNA折纸
DNA纳米技术
药物输送
自组装
生物传感器
A-DNA
分子机器
生物物理学
计算生物学
纳米技术
生物化学
酶
分子生物学
生物
材料科学
有机化学
作者
Qian Li,Longfei Liu,Dake Mao,Yuyan Yu,Weili Li,Xinfeng Zhao,Chengde Mao
摘要
Responsive self-assembly is a general process in biological systems and is highly desired in engineered systems. DNA nanostructures provide a versatile molecular platform for studying such responsive self-assembly. Various triggers have been explored for DNA nanostructures. However, each trigger requires a unique mechanism for its response. This situation brings a great challenge to engineer the responsiveness. Herein, we propose an aptamer-based, allosteric mechanism for responsive DNA self-assembly. The aptamer–ligand binding causes the DNA motif to change its conformation and thus influences the motif assembly. With a model of an ATP aptamer, we have demonstrated the responsive assembly. Such responsive behavior, we believe, will be an important element for molecular machines, bioimaging/biosensing, and drug delivery.
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