生物
仿形(计算机编程)
细胞
计算生物学
细胞生物学
基因表达谱
多样性(政治)
单细胞分析
基因表达
基因
遗传学
计算机科学
人类学
操作系统
社会学
作者
Daniel A. Skelly,Galen T. Squiers,Micheal A. McLellan,Mohan Bolisetty,Paul Robson,Nadia Rosenthal,Alexander R. Pinto
出处
期刊:Cell Reports
[Elsevier]
日期:2018-01-01
卷期号:22 (3): 600-610
被引量:479
标识
DOI:10.1016/j.celrep.2017.12.072
摘要
Characterization of the cardiac cellulome, the network of cells that form the heart, is essential for understanding cardiac development and normal organ function and for formulating precise therapeutic strategies to combat heart disease. Recent studies have reshaped our understanding of cardiac cellular composition and highlighted important functional roles for non-myocyte cell types. In this study, we characterized single-cell transcriptional profiles of the murine non-myocyte cardiac cellular landscape using single-cell RNA sequencing (scRNA-seq). Detailed molecular analyses revealed the diversity of the cardiac cellulome and facilitated the development of techniques to isolate understudied cardiac cell populations, such as mural cells and glia. Our analyses also revealed extensive networks of intercellular communication and suggested prevalent sexual dimorphism in gene expression in the heart. This study offers insights into the structure and function of the mammalian cardiac cellulome and provides an important resource that will stimulate studies in cardiac cell biology.
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