姜黄素
医学
动脉硬化
氧化应激
一氧化氮
内皮功能障碍
冠状动脉疾病
生物利用度
疾病
血管疾病
心血管健康
炎症
药理学
生物信息学
内科学
血压
生物
作者
Marilyn S. Campbell,Bradley S. Fleenor
标识
DOI:10.1080/10408398.2017.1341865
摘要
Curcumin, when administered in a bioavailable form, has potential to influence vascular health of various populations, leading to decreases in cardiovascular disease risk. Clinical intervention studies with curcumin have demonstrated significant improvements in endothelial function, arterial compliance, arterial stiffness, and other measures of vascular hemodynamics in young, middle-aged, old, post-menopausal, healthy, diabetic, and obese individuals. Mechanistically, curcumin is believed to improve vascular function through its effects on inflammation, oxidative stress, nitric oxide bioavailability, and structural proteins of the artery. Current data give support for curcumin to be administered for improvements in vascular health to individuals that may or may not be at risk for cardiovascular disease. This review briefly summarizes the techniques used for the establishment of vascular health and overviews the literature investigating the role of curcumin in the improvement of vascular health.
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