壳聚糖
纳米载体
纳米材料
纳米技术
药物输送
生物相容性
凝聚
材料科学
纳米颗粒
生物相容性材料
化学
毒品携带者
靶向给药
色谱法
有机化学
冶金
作者
Yu Yang,Shengpeng Wang,Ying Wang,Xiaohui Wang,Qun Wang,Meiwan Chen
标识
DOI:10.1016/j.biotechadv.2014.07.007
摘要
Nanomaterials based on chitosan have emerged as promising carriers of therapeutic agents for drug delivery due to good biocompatibility, biodegradability, and low toxicity. Chitosan originated nanocarriers have been prepared by mini-emulsion, chemical or ionic gelation, coacervation/precipitation, and spray-drying methods. As alternatives to these traditional fabrication methods, self-assembled chitosan nanomaterials show significant advantages and have received growing scientific attention in recent years. Self-assembly is a spontaneous process by which organized structures with particular functions and properties could be obtained without additional complicated processing or modification steps. In this review, we focus on recent progress in the design, fabrication and physicochemical aspects of chitosan-based self-assembled nanomaterials. Their applications in drug delivery of different therapeutic agents are also discussed in details.
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