Perioperative concentrations of catecholamines in the cerebrospinal fluid and plasma during spinal anesthesia

医学 儿茶酚胺 肾上腺素 麻醉 去甲肾上腺素 脑脊液 围手术期 多巴胺 四分位间距 内科学 内分泌学
作者
M. J. Oehmke,Tobias Podranski,M. Mann,Nathalie Frickey,D. Kuhn,G. Hempelmann
出处
期刊:Acta Anaesthesiologica Scandinavica [Wiley]
卷期号:52 (4): 487-492 被引量:10
标识
DOI:10.1111/j.1399-6576.2007.01551.x
摘要

Background: Catecholamine release is a physiological response to stress. The extent to which perioperative stress provokes the central release of catecholamines, which modulate pain perception in the spinal cord, still remains unknown. The perioperative course of catecholamine concentrations in the cerebrospinal fluid (CSF) and plasma was examined. Methods: A prospective study was performed in 25 patients (ASA III, 60–84 years) undergoing elective hip joint replacement in spinal catheter anesthesia. The concentrations of dopamine, epinephrine and norepinephrine in the CSF and plasma were measured before anesthesia, immediately after surgery, and 6 and 24 h post‐operatively. Results: In most patients, dopamine and epinephrine were not detectable in CSF. CSF–norepinephrine concentrations decreased from median [interquartile‐range] 159 [124;216] pre‐anesthesia to 116 [79;152] pmol/l immediately post‐operatively and were slightly elevated 24 h post‐operatively (180 [134;302] pmol/l) ( P =0.05). Dopamine plasma concentrations were not detectable or were barely above the detection threshold. Plasma epinephrine increased from 61 [28;77] pmol/l pre‐anesthesia to 112 [69;138] pmol/l 6 h post‐operatively and returned to baseline 24 h post‐operatively ( P =0.001). Plasma norepinephrine concentrations increased intra‐operatively from 298 [249;422] to 556 [423;649] pmol/l and remained elevated 24 h after surgery ( P =0.009). There was no association between changes in CSF or plasma norepinephrine or epinephrine concentrations and changes in heart rate (HR) or mean arterial pressure (MAP). Conclusion: During spinal anesthesia for elective hip joint replacement, norepinephrine concentrations were greater in plasma than in CSF. CSF dopamine and epinephrine concentrations were essentially undetectable. The changes in CSF‐norepinephrine concentrations and the changes of plasma norepinephrine concentrations showed no association with each other; nor were there correlations between clinical stress parameters (HR, MAP) or visual analog scale pain, and the changes in CSF norepinephrine concentrations.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
2秒前
2秒前
2秒前
4秒前
Owen应助晒太阳的加菲猫采纳,获得10
5秒前
anna发布了新的文献求助10
7秒前
7秒前
wu基督教发布了新的文献求助10
8秒前
9秒前
余南发布了新的文献求助10
10秒前
晒太阳的加菲猫完成签到,获得积分10
10秒前
笑点低诗桃完成签到,获得积分20
11秒前
泡泡脑瓜完成签到,获得积分10
11秒前
13秒前
liche发布了新的文献求助10
13秒前
14秒前
修管子发布了新的文献求助10
14秒前
15秒前
共享精神应助gx采纳,获得10
15秒前
高手完成签到,获得积分20
16秒前
无所谓的啦完成签到,获得积分10
16秒前
ylq关闭了ylq文献求助
17秒前
wu基督教完成签到,获得积分20
17秒前
18秒前
迷人的芹菜完成签到,获得积分10
18秒前
19秒前
Miracle发布了新的文献求助10
19秒前
高手发布了新的文献求助10
20秒前
20秒前
我啊完成签到 ,获得积分10
23秒前
slp发布了新的文献求助30
24秒前
24秒前
gx发布了新的文献求助10
26秒前
英姑应助笑点低诗桃采纳,获得10
28秒前
youwenjing11发布了新的文献求助10
28秒前
王铂然发布了新的文献求助10
31秒前
大模型应助GGBOND采纳,获得10
32秒前
脑洞疼应助gx采纳,获得10
32秒前
Eunice完成签到,获得积分10
33秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989115
求助须知:如何正确求助?哪些是违规求助? 3531367
关于积分的说明 11253688
捐赠科研通 3269986
什么是DOI,文献DOI怎么找? 1804868
邀请新用户注册赠送积分活动 882078
科研通“疑难数据库(出版商)”最低求助积分说明 809105