Mo1947 Co-Treatment With Statin May Prevent Development of Barrett's Esophagus Among Japanese Patients Taking Low Doses of Aspirin

Results: BEC-40 weeks and BEC-60 weeks had significantly higher proliferation rates compared to BEC-0 weeks and BEC-20 weeks (See Table 1).Although there was no statistically significant difference in proliferation rate between BEC-0 week and 20 week cells, the BEC-60 week cells grew 2.75 fold higher compared to BEC-40 week cells.The apoptosis rate showed a reverse pattern with a 50 % suppression in BEC-60 week cells compared to BEC-0 week cells.Serum-deprivation induced a 5.4-fold reduction in proliferation rate in BEC-60 week cells compared to the BEC-40 week cells.Conclusion: The transformed BEC-60 week cells proliferate at a faster rate than BEC-0 weeks, 20 weeks, and 40 week cells.They also appear to be more resistant to apoptosis as a consequence of B4 exposure.However, proliferation of BEC-60 weeks is most affected by serum deprivation.Increased proliferation, reduced apoptosis, and serum dependence due to chronic B4 exposure in BEC cells are likely properties of dysplasia and neoplasia observed in BE progression to esophageal adenocarcinoma in vivo.We propose that this dynamic novel BEC model may be applied for future chemoprevention studies for BE-carcinogenesis.Table 1: Fold change between different phases of the BEC model in the presence and absence of serum in growth medium Mo1947