溃疡性结肠炎
炎症性肠病
促炎细胞因子
免疫学
医学
肿瘤坏死因子α
免疫系统
克罗恩病
疾病
结肠炎
炎症
内科学
作者
Gabriela Fonseca‐Camarillo,Jesús K. Yamamoto-Furusho
出处
期刊:Inflammatory Bowel Diseases
[Oxford University Press]
日期:2015-09-01
卷期号:21 (9): 2188-2193
被引量:81
标识
DOI:10.1097/mib.0000000000000477
摘要
Inflammatory bowel diseases (IBD) include ulcerative colitis and Crohn's disease. The immune response in ulcerative colitis is different from the Crohn's disease. Accumulating evidence suggests that IBD results from an inappropriate inflammatory response to intestinal microbes in a genetically susceptible host. Several immunoregulatory abnormalities have been reported in patients with IBD, including the ratio of proinflammatory (tumor necrosis factor alpha, IL-6, IL-1-β) to immunoregulatory cytokines (IL-10, TGF-β, IL-35) and selective activation of T-helper (Th) lymphocyte subsets (Th1, Th2, Th9, Th17, and regulatory T cells). The purpose of this review is to show the immunoregulatory pathways (regulatory cells and cytokines) involved in IBD published in recent years.
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