小胶质细胞
免疫系统
性二态性
慢性疼痛
神经科学
免疫学
医学
心理学
炎症
内分泌学
作者
Robert E. Sorge,Josiane C.S. Mapplebeck,Sarah F. Rosen,Simon Beggs,Sarah Taves,Jessica Alexander,Loren J. Martin,Jean‐Sebastien Austin,Susana G. Sotocinal,Di Chen,Mu Yang,Xiang Shi,Hao Huang,Nicolas J. Pillon,Philip J. Bilan,YuShan Tu,Amira Klip,Ru‐Rong Ji,Ji Zhang,Michael W. Salter,Jeffrey S. Mogil
摘要
A large and rapidly increasing body of evidence indicates that microglia-to-neuron signaling is essential for chronic pain hypersensitivity. Using multiple approaches, we found that microglia are not required for mechanical pain hypersensitivity in female mice; female mice achieved similar levels of pain hypersensitivity using adaptive immune cells, likely T lymphocytes. This sexual dimorphism suggests that male mice cannot be used as proxies for females in pain research.
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