纳米医学
癌症
癌症研究
癌症治疗
纳米载体
生物物理学
体内
计算机科学
化学
肿瘤微环境
作者
Xiaonan An,Aijun Zhu,Huanhuan Luo,Hengte Ke,Huabing Chen,Youliang Zhao
出处
期刊:ACS Nano
[American Chemical Society]
日期:2016-06-10
卷期号:10 (6): 5947-5958
被引量:183
标识
DOI:10.1021/acsnano.6b01296
摘要
Stimuli-responsive nanoparticles with target capacity are of great interest in drug delivery for cancer therapy. However, the challenge is to achieve highly smart release with precise spatiotemporal control for cancer therapy. Herein, we report the preparation and properties of multi-stimuli-responsive nanoparticles through the co-assembly of a 3-arm star quaterpolymer with a near-infrared (NIR) photothermal agent and chemotherapeutic compound. The nanoparticles can exhibit NIR light/pH/reduction-responsive drug release and intracellular drug translocation in cancer cells, which further integrate photoinduced hyperthermia for synergistic anticancer efficiency, thereby leading to tumor ablation without tumor regrowth. Thus, this rational design of nanoparticles with multiple responsiveness represents a versatile strategy to provide smart drug delivery paradigms for cancer therapy.
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