Effects of Sodium Cantharidinate and Vitamin B6 Injection on Plasma D-dimer Level in Patients of Advanced Esophageal Cancer after Chemotherapy

Objective To explore the effect of sodium cantharidinate and vitamin B6 injection on plasma D-dimerlevel in patients of advanced esophageal cancer after chemotherapy and the relationship between plasma D-dimer level andclinical pathological parameters thereof. Methods Fifty-eight patients with advanced esophageal cancer confirmed by path-ological examination were randomly divided into two groups. Twenty-nine patients(experimental group) received chemother-apy(PF chemotherapy) combined with sodium cantharidinate and vitamin B6(0.5 mg once daily). Twenty-nine patients(con-trol group) received same volume of saline. And there were 20 healthy volunteers as the normal control. The plasma D-dimerlevel was determined one day before the first cycle of chemotherapy and the third cycle of treatment. Results The plasmaD-dimer level was significantly higher before chemotherapy in patients with advanced esophageal cancer than that in normalcontrol group(P 0.05). There were no significant differences in plasma D-dimer level between patient gender, age, clinicalstage and pathological levels. The D-dimer level was significantly down-regulated after chemotherapy. The D-dimer levelwas significantly lower in experimental group than that in control group(P 0.05). The incidences of digestive and hemato-logical adverse reactions were much lower in experimental group than those in control group. Conclusion The elevatedplasma D-dimer level was found in patients with advanced esophageal cancer, and which was down-regulated by chemother-apy. The chemotherapy of sodium cantharidinate and vitamin B6 can further reduce the D-dimer level, and relieve the ad-verse reactions of chemotherapy.