Preparation and quality control of mometasone furoate gel

Objective To establish the preparation and a method of quality control of mometasone furoate intranasal gel. Methods The mometasone furoate intranasal gel was prepared by Xanthan gum as base material.The content of mometasone furoate was determined by ultraviolet spectrophotometry. Results The calibration curve was good linear in the range from 1 μg/mL to 100 μg/mL(r=0.999 9).The average recovery was 100.6%. Conclusions The preparation of gel is simple.The quality of gel is stable and controlled.The new mometasone furoate gel is effective in allergic rhinitis.