Study on Ursodeoxycholic Acid in Treatment of Primary Sclerosing Cholangitis

Primary sclerosing cholangitis(PSC) is an unexplained cholestatic liver disease,and genetic predisposition and environmental factors are possibly responsible for it.Ursodeoxycholic acid(UDCA)is beneficial for cholestatic liver diseases.In primary sclerosing cholangitis(PSC),evidences show that high doses(±20 mg/kg)of UDCA may be more effective than average doses.This article reports on the clinical effect of UDCA in the treatment of PSC with analysis based on literature.