Receptor‐Fc and Ligand Traps as High‐Affinity Biological Blockers: Development and Clinical Applications

This chapter contains sections titled: Introduction Etanercept as a Prototypical Receptor-Fc-Based Cytokine Blocker Heteromeric Traps for Ligands Utilizing Multicomponent Receptor Systems with Shared Subunits Development and Clinical Application of an Interleukin 1 Trap: Rilonacept Development and Clinical Application of a VEGF Trap "To Trap Or Not To Trap?" Advantages and Disadvantages of Receptor-Fc Fusions and Traps Versus Antibodies Conclusion Acknowledgment References