Solid-Phase Synthesis of Cyclic Peptide−DNA Hybrids

A methodology for preparing cyclic peptide−DNA hybrids on controlled pore glass in high yield is reported. This methodology employs Fmoc/Alloc-protected amino acid and nucleoside phosphoramidites on an ω-hydroxylauric acid-derivatized support and is suitable for library synthesis. A cyclic hybrid of the sequence Glu-Leu-T*T-DP-Lys, where Glu and Lys are linked and T* denotes a 5'-amino-5'-deoxynucleotide, exhibited high resistance to exo- and endonucleases.