丙烯腈
部分
化学
组合化学
利比韦林
有机化学
医学
人类免疫缺陷病毒(HIV)
共聚物
病毒载量
家庭医学
聚合物
抗逆转录病毒疗法
作者
Oya Ünsal Tan,Merve Zengin
标识
DOI:10.1002/ardp.202100383
摘要
Acrylonitrile is a fascinating scaffold widely found in many natural products, drugs, and drug candidates with various biological activities. Several drug molecules such as entacapone, rilpivirine, teriflunomide, and so forth, bearing an acrylonitrile moiety have been marketed. In this review, diverse synthetic strategies for constructing desired acrylonitriles are discussed, and the different biological activities and medicinal significance of various acrylonitrile derivatives are critically evaluated. The information gathered is expected to provide rational guidance for the development of clinically useful agents from acrylonitriles.
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