炎症体
上睑下垂
炎症
目标2
细胞生物学
半胱氨酸蛋白酶1
吡喃结构域
化学
生物
分泌物
促炎细胞因子
生物化学
免疫学
作者
Chun Wang,Tong Yang,Jianqiu Xiao,Canxin Xu,Yael Alippe,Kai Sun,Thirumala‐Devi Kanneganti,Joseph B. Monahan,Yousef Abu‐Amer,Judy Lieberman,Gabriel Mbalaviele
出处
期刊：Science immunology
[American Association for the Advancement of Science]
日期：2021-10-23
卷期号：6 (64): eabj3859-eabj3859
被引量：296
标识
DOI：10.1126/sciimmunol.abj3859
摘要
mice. Thus, NLRP3 inflammasome activation overwhelms the protection afforded by GSDMD deficiency, rewiring signaling cascades through mechanisms that include GSDME to propagate inflammation.
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