已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

1‐Hydroxypyrene mediates renal fibrosis through aryl hydrocarbon receptor signalling pathway

芳香烃受体 代谢物 肾脏疾病 CYP1B1型 肾功能 化学 药理学 纤维化 内科学 受体 生物 生物化学 医学 新陈代谢 细胞色素P450 基因 转录因子
作者
Hua Miao,Xia‐Qing Wu,Yanni Wang,Dan‐Qian Chen,Lin Chen,Nosratola D. Vaziri,Shougang Zhuang,Yan Guo,Su Wei,Shixing Ma,Huan‐Qiao Zhang,You‐Quan Shang,Xiao‐Yong Yu,Yan‐Long Zhao,Jiarong Mao,Ming Gao,Jinhua Zhang,Jin Zhao,Yuan Zhang,Zhang Li,Ying‐Yong Zhao,Gang Cao
出处
期刊:British Journal of Pharmacology [Wiley]
卷期号:179 (1): 103-124 被引量:30
标识
DOI:10.1111/bph.15705
摘要

In chronic kidney disease (CKD), patients inevitably reach end-stage renal disease and require renal transplant. Evidence suggests that CKD is associated with metabolite disorders. However, the molecular pathways targeted by metabolites remain enigmatic. Here, we describe roles of 1-hydroxypyrene in mediating renal fibrosis.We analysed 5406 urine and serum samples from patients with Stage 1-5 CKD using metabolomics, and 1-hydroxypyrene was identified and validated using longitudinal and drug intervention cohorts as well as 5/6 nephrectomised and adenine-induced rats.We identified correlations between the urine and serum levels of 1-hydroxypyrene and the estimated GFR in patients with CKD onset and progression. Moreover, increased 1-hydroxypyrene levels in serum and kidney tissues correlated with decreased renal function in two rat models. Up-regulated mRNA expression of aryl hydrocarbon receptor and its target genes, including CYP1A1, CYP1A2 and CYP1B1, were observed in patients and rats with progressive CKD. Further we showed up-regulated mRNA expression of aryl hydrocarbon receptor and its three target genes, plus up-regulated nuclear aryl hydrocarbon receptor protein levels in mice and HK-2 cells treated with 1-hydroxypyrene, which caused accumulation of extracellular matrix components. Treatment with aryl hydrocarbon receptor short hairpin RNA or flavonoids inhibited mRNA expression of aryl hydrocarbon receptor and its target genes in 1-hydroxypyrene-induced HK-2 cells and mice.Metabolite 1-hydroxypyrene was demonstrated to mediate renal fibrosis through activation of the aryl hydrocarbon receptor signalling pathway. Targeting aryl hydrocarbon receptor may be an alternative therapeutic strategy for CKD progression.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
大脸猫4811完成签到,获得积分10
刚刚
1秒前
iriswong9501发布了新的文献求助10
1秒前
Yuantian发布了新的文献求助10
1秒前
Akim应助LMH采纳,获得10
5秒前
缓慢天菱发布了新的文献求助10
6秒前
火神杯发布了新的文献求助10
11秒前
黄花菜完成签到 ,获得积分10
12秒前
刘天宇完成签到 ,获得积分10
14秒前
14秒前
17秒前
Julie完成签到,获得积分20
17秒前
bukeshuo发布了新的文献求助10
18秒前
18秒前
19秒前
火神杯完成签到,获得积分10
26秒前
个性的紫菜应助火神杯采纳,获得10
30秒前
焱焱不忘完成签到 ,获得积分10
31秒前
orixero应助Julie采纳,获得10
32秒前
34秒前
myn1990发布了新的文献求助10
39秒前
41秒前
阿a完成签到,获得积分10
42秒前
Benjamin完成签到 ,获得积分10
42秒前
46秒前
Jasper应助耶嘿采纳,获得10
51秒前
bukeshuo发布了新的文献求助30
52秒前
阿a发布了新的文献求助20
53秒前
myn1990完成签到,获得积分20
56秒前
1分钟前
JacobWang发布了新的文献求助10
1分钟前
bukeshuo发布了新的文献求助10
1分钟前
Nakjeong完成签到 ,获得积分10
1分钟前
qianchang完成签到,获得积分10
1分钟前
Kevin完成签到 ,获得积分10
1分钟前
风趣半莲完成签到,获得积分10
1分钟前
本尼脸上褶子完成签到 ,获得积分10
1分钟前
cc完成签到 ,获得积分10
1分钟前
1分钟前
JacobWang完成签到,获得积分10
1分钟前
高分求助中
Evolution 10000
Sustainability in Tides Chemistry 2800
The Young builders of New china : the visit of the delegation of the WFDY to the Chinese People's Republic 1000
юрские динозавры восточного забайкалья 800
English Wealden Fossils 700
Foreign Policy of the French Second Empire: A Bibliography 500
Chen Hansheng: China’s Last Romantic Revolutionary 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3146684
求助须知:如何正确求助?哪些是违规求助? 2798001
关于积分的说明 7826352
捐赠科研通 2454503
什么是DOI,文献DOI怎么找? 1306289
科研通“疑难数据库(出版商)”最低求助积分说明 627692
版权声明 601522