血管免疫母细胞性T细胞淋巴瘤
病理
淋巴瘤
针吸细胞学
组织病理学
上皮样细胞
淋巴增生
单变量分析
医学
细胞学
淋巴结
细针穿刺
活检
免疫组织化学
T细胞
多元分析
内科学
免疫学
免疫系统
作者
Parikshaa Gupta,Nalini Gupta,Amanjit Bal,Pulkit Rastogi,Gaurav Prakash,Pankaj Malhotra,Pranab Dey,Radhika Srinivasan,Ashim Das
标识
DOI:10.1136/jclinpath-2021-207887
摘要
Angioimmunoblastic T cell lymphoma (AITL) is often misdiagnosed in cytology. Hence, the present study was conducted to identify the distinctive cytomorphological features of AITL in lymph node fine-needle aspirates (LN-FNA).This was a 4-year retrospective case-control study. Cases included LN-FNAs from patients with histopathologically confirmed AITL. The controls included LN-FNAs from patients with histopathologically confirmed reactive lymphoid hyperplasia (RLH; n=25). Eleven cytomorphological features were assessed in all the aspirates; the strength of association was determined by OR, Cramer's V and multiple correspondence analysis (MCA).Of a total of 22 cases of AITL reported on histopathology, 19 adequate aspirates from 14 patients (63.6%) were available for review. On univariate analysis, 5 of 11 cytomorphological variables were found to be significant for AITL; however, on MCA, 3 of these parameters, viz absence of tingible body macrophages (OR=0.014; V=0.74), presence of atypical lymphoid cells (OR=10.8; V=0.41) and singly scattered epithelioid cells (OR=19.3; V=0.31), were found to be the strongest predictors of AITL.The absence of tingible body macrophages, presence of atypical lymphoid cells and singly scattered epithelioid cells in polymorphic LN-FNAs are significant cytomorphological predictors of AITL in comparison with RLH. Knowledge of these diagnostic predictors, supplemented by clinicoradiological correlation and appropriate ancillary studies, can help diagnose AITL on aspiration cytology.
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