Lectin-like oxidized low-density lipoprotein receptor-1 and atherosclerosis

Lectin-like oxidized LDL receptor-1 (LOX-1) is one of the major receptors of the oxidized low-density lipoproteins (oxLDL). Recent research suggests that LOX-1 can not only bind, neutralize and degrade oxLDL, but also bind some non-oxidized lipoproteins and apoptotic blood cells. LOX-1 is involved in the process of atherosclerosis through a variety of ways, such as activating platelet, inducing inflammatory reaction, promoting the proliferation and migration of vascular smooth muscle cells. This article reviews the related research progress from the relationship between the structure and function of the LOX-1 and its lipid metabolism and the pathogenesis of atherosclerosis. Key words: Atherosclerosis; Scavenger Receptors, Class E; Lipoproteins, LDL; Inflammation