戒指(化学)
化学
茚
药物化学
Atom(片上系统)
作者
Yuanyang Mu,Qiyi Yao,Liqiang Yin,Siyi Fu,Mengdan Wang,Yuan Yang,Lingkai Kong,Yanzhong Li
标识
DOI:10.1021/acs.joc.1c00487
摘要
An atom economic procedure for the regioselective synthesis of bridged seven-membered-ring compounds from simple reactants such as ynones and indene-1,3-dione has been developed. This process was realized through the one-pot reactions of ring-expansion of indene-1,3-dione with alkynyl ketones and successive formal [4+2] cycloaddition. The Michael addition reaction is the key for the regioselectivity of the formal [4+2] cycloaddition.
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