明胶
自愈水凝胶
伤口愈合
伤口敷料
自愈
材料科学
高分子化学
高分子科学
化学工程
化学
复合材料
外科
有机化学
医学
病理
替代医学
工程类
作者
Birgit Stubbe,Arn Mignon,Lana Van Damme,Karel Claes,Henk Hoeksema,Stan Monstrey,Sandra Van Vlierberghe,Peter Dubruel
标识
DOI:10.1002/mabi.202100246
摘要
Abstract Gelatin is used widely in the biomedical field, among other for wound healing. Given its upper critical solution temperature, crosslinking is required. To this end, gelatin is chemically modified with different photo‐crosslinkable moieties with low (32–34%) and high (63–65%) degree of substitution (DS): gelatin‐methacrylamide (gel‐MA) and gelatin‐acrylamide (gel‐AA) and gelatin‐pentenamide (gel‐PE). Next to the more researched gel‐MA, it is especially interesting and novel to compare with other gelatin‐derived compounds for the application of wound healing. An additional comparison is made with commercial dressings. The DS is directly proportional to the mechanical characteristics and inversely proportional to the swelling capacity. Gel‐PE shows weaker mechanical properties ( G ′ < 15 kPa) than gel‐AA and gel‐MA ( G ′ < 39 and 45 kPa, respectively). All derivatives are predominantly elastic (recovery indices of 89–94%). Gel‐AA and gel‐MA show excellent biocompatibility, whereas gel‐PE shows a significantly lower initial biocompatibility, evolving positively toward day 7. Overall, gel‐MA shows to have the most potential to be applied as wound dressing. Future blending with gel‐AA to improve the curing kinetics can lead to dressings able to compete with current commercial dressings.
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