Bone pain from spinal metastases: Iodine-125 brachytherapy

近距离放射治疗 医学 止痛药 放射治疗 外照射放疗 放射科 核医学 麻醉
作者
Hongxue Shao,Lei Teng,Junzhu Dai,Wenhui Zhang,Shiyan Lin,Liuyuan Zhao,Huichao Zou
出处
期刊:BMJ supportive & palliative care [BMJ]
卷期号:: bmjspcare-003285 被引量:1
标识
DOI:10.1136/bmjspcare-2021-003285
摘要

Objectives This study evaluated the analgesic efficacy and safety of CT-guided iodine-125 ( 125 I) brachytherapy in patients with spinal metastasis-induced pain who were not suitable to receive radiotherapy. Methods A cohort of 68 patients with spinal metastasis induced pain not fully relieved by opioids and did not receive external beam radiation therapy due to poor general status were enrolled and underwent CT-guided 125 I brachytherapy for analgesic treatment. Results Patients were followed for 8 weeks after brachytherapy. Mean Numerical Rating Scale score before brachytherapy was 7.3±1.3 and decreased to 3.3±0.9, 2.6±0.8, 2.7±0.8, 2.9±0.9 and 3.3±1.1 at weeks 1, 2, 4, 6 and 8, respectively, after brachytherapy. Daily dose of morphine equivalent was 105.1±28.0 mg before brachytherapy and decreased to 45.3±13.7, 39.9±14.2, 40.4±14.9, 48.5±18.0 and 62.4±17.5 mg at weeks 1, 2, 4, 6 and 8, respectively, after brachytherapy. Patients had fewer daily episodes of breakthrough pain after brachytherapy (p<0.001). Patients had improvement in pain-related functional interference and in hospital anxiety and depression score after brachytherapy. Conclusions CT-guided 125 I brachytherapy is an effective and safe intervention for patients with spinal metastasis-induced pain who are not able to receive radiation therapy.

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
wanci应助淡定可乐采纳,获得10
1秒前
通达完成签到,获得积分10
1秒前
丘比特应助小慧采纳,获得10
2秒前
正宗三十六妹完成签到,获得积分10
3秒前
4秒前
bkagyin应助万康采纳,获得10
7秒前
Mary完成签到 ,获得积分20
7秒前
星辰大海应助笑点低诗双采纳,获得10
7秒前
8秒前
13秒前
王艺霖发布了新的文献求助10
13秒前
Dobronx03完成签到,获得积分10
14秒前
ccmia发布了新的文献求助10
14秒前
小慧发布了新的文献求助10
14秒前
落寞依珊完成签到,获得积分10
15秒前
15秒前
16秒前
18秒前
19秒前
不倦应助998877剑指采纳,获得10
19秒前
Hana完成签到,获得积分10
19秒前
西贝发布了新的文献求助10
20秒前
落寞依珊发布了新的文献求助10
20秒前
abc发布了新的文献求助10
21秒前
CipherSage应助小慧采纳,获得10
21秒前
21秒前
Dobronx03完成签到,获得积分10
22秒前
23秒前
Akim应助笑点低诗双采纳,获得10
24秒前
香菜兔子完成签到,获得积分10
24秒前
充电宝应助鳗鱼焦采纳,获得10
25秒前
Akim应助ccmia采纳,获得10
25秒前
25秒前
imomoe完成签到,获得积分10
27秒前
27秒前
28秒前
CHENJIRU发布了新的文献求助10
28秒前
自由的蛋挞完成签到,获得积分10
30秒前
30秒前
不倒立应助橡皮泥采纳,获得10
31秒前
高分求助中
Continuum Thermodynamics and Material Modelling 3000
Production Logging: Theoretical and Interpretive Elements 2700
Les Mantodea de Guyane Insecta, Polyneoptera 1000
Structural Load Modelling and Combination for Performance and Safety Evaluation 1000
Conference Record, IAS Annual Meeting 1977 820
England and the Discovery of America, 1481-1620 600
電気学会論文誌D(産業応用部門誌), 141 巻, 11 号 510
热门求助领域 (近24小时)
化学 材料科学 生物 医学 工程类 有机化学 生物化学 物理 纳米技术 计算机科学 内科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 量子力学 光电子学 冶金
热门帖子
关注 科研通微信公众号,转发送积分 3572113
求助须知:如何正确求助?哪些是违规求助? 3142407
关于积分的说明 9447535
捐赠科研通 2843832
什么是DOI,文献DOI怎么找? 1563100
邀请新用户注册赠送积分活动 731590
科研通“疑难数据库(出版商)”最低求助积分说明 718612