组学
精密医学
代谢组学
疾病
仿形(计算机编程)
生物信息学
计算生物学
脂肪肝
2型糖尿病
代谢综合征
表观遗传学
蛋白质组学
系统生物学
医学
个性化医疗
基因组学
生物
生物标志物发现
转录组
代谢组
蛋白质组
糖尿病
遗传学
计算机科学
内科学
基因组
基因
内分泌学
操作系统
摘要
Metabolic diseases including type 2 diabetes mellitus (T2DM), non-alcoholic fatty liver disease (NAFLD), and metabolic syndrome (MetS) are alarming health burdens around the world, while therapies for these diseases are far from satisfying as their etiologies are not completely clear yet. T2DM, NAFLD, and MetS are all complex and multifactorial metabolic disorders based on the interactions between genetics and environment. Omics studies such as genetics, transcriptomics, epigenetics, proteomics, and metabolomics are all promising approaches in accurately characterizing these diseases. And the most effective treatments for individuals can be achieved via omics pathways, which is the theme of precision medicine. In this review, we summarized the multi-omics studies of T2DM, NAFLD, and MetS in recent years, provided a theoretical basis for their pathogenesis and the effective prevention and treatment, and highlighted the biomarkers and future strategies for precision medicine.
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