医学
移植
免疫疗法
器官移植
免疫学
治疗方法
细胞疗法
人口
临床试验
免疫系统
细胞
内科学
生物
疾病
遗传学
环境卫生
作者
Nina Pilat,Katia Lefsihane,Sophie Brouard,Katja Kotsch,Christine S. Falk,Romy Steiner,Olivier Thaunat,Floriane Fusil,Núria Montserrat,Cristiano Amarelli,Federica Casiraghi
摘要
Cell therapy has emerged as an attractive therapeutic option in organ transplantation. During the last decade, the therapeutic potency of Treg immunotherapy has been shown in various preclinical animal models and safety was demonstrated in first clinical trials. However, there are still critical open questions regarding specificity, survival, and migration to the target tissue so the best Treg population for infusion into patients is still under debate. Recent advances in CAR technology hold the promise for Treg-functional superiority. Another exciting strategy is the generation of B-cell antibody receptor (BAR) Treg/cytotoxic T cells to specifically regulate or deplete alloreactive memory B cells. Finally, B cells are also capable of immune regulation, making them promising candidates for immunomodulatory therapeutic strategies. This article summarizes available literature on cell-based innovative therapeutic approaches aiming at modulating alloimmune response for transplantation. Crucial areas of investigation that need a joined effort of the transplant community for moving the field toward successful achievement of tolerance are highlighted.
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