亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

An ultrasmall infinite coordination polymer nanomedicine-composited biomimetic hydrogel for programmed dressing-chemo-low level laser combination therapy of burn wounds

伤口愈合 自愈水凝胶 材料科学 纳米医学 生物医学工程 止血 纳米复合材料 透明质酸 药物输送 纳米技术 纳米颗粒 化学 高分子化学 外科 医学 解剖
作者
Shihong Shen,Daidi Fan,Yuan Yang,Xiaoxuan Ma,Jing Zhao,Jing Yang
出处
期刊:Chemical Engineering Journal [Elsevier BV]
卷期号:426: 130610-130610 被引量:82
标识
DOI:10.1016/j.cej.2021.130610
摘要

To programmatically promote burn wound healing in a way that was tailored to the complex healing phases of hemostasis, anti-inflammation, proliferation, and remolding, we proposed a combined therapeutic strategy of dressing management-chemotherapy-low level laser therapy (LLLT), and designed a highly integrated and simply-structured nanocomposite hydrogel with properties of transparency, self-monitored pH-responsive drug release, and burn wound-adaptability (shape-remodeling, self-healing, and tissue-adhesion). This nanocomposite hydrogel was composed of oxidized hyaluronic acid (OHA), ε-poly-L-lysine grafted human-like collagen (HLC-EPL) and a versatile curcumin-Fe(III) infinite coordination polymer nanomedicines (Cur-Fe(III) ICPs), which were dual dynamically cross-linked via imine bonds and nanoparticle-polymer interactions. The minimized light scattering and absorption of carrier-free and ultrasmall (9.14 ± 1.25 nm) Cur-Fe(III) ICPs and the low refractive index contrast with water of HLC-EPL and OHA endowed the nanocomposite hydrogel with a light transmittance of ≥ 90.1% at 904 nm, which made it compatible with LLLT. The dynamic crosslinking site-rich surface of the Cur-Fe(III) ICPs improved the shape-remodeling and self-healing efficiency of dressing, which resulted in an 84.6% cross-linking reconstruction efficiency within 10 min, thus making it more adaptive to burn wounds. The programmed therapy was implemented by the autoprogressed intrinsic procoagulant activity of HLC-EPL and physical sealing effect in the hemostasis phase, pH-responsive chemotherapy of Cur-Fe(III) ICPs in the inflammation phase, and spatiotemporally controllable LLLT in the proliferation and remodeling phases. As a result, the closure period of full-thickness burn wounds was greatly shortened from 21 to 9 days, and the reconstruction of skin structure was accelerated.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
7秒前
宋雨航发布了新的文献求助10
14秒前
41秒前
Ying发布了新的文献求助20
46秒前
风吹而过完成签到 ,获得积分10
53秒前
breeze完成签到,获得积分10
1分钟前
佳思思完成签到,获得积分10
1分钟前
1分钟前
草木完成签到 ,获得积分20
1分钟前
英俊的铭应助科研通管家采纳,获得10
1分钟前
所所应助科研通管家采纳,获得10
1分钟前
科研通AI2S应助科研通管家采纳,获得10
1分钟前
叫滚滚发布了新的文献求助20
1分钟前
vitamin完成签到 ,获得积分10
1分钟前
情怀应助叫滚滚采纳,获得10
1分钟前
1分钟前
2分钟前
叫滚滚发布了新的文献求助10
2分钟前
2分钟前
2分钟前
gyh发布了新的文献求助10
2分钟前
Owen应助獭兔采纳,获得10
2分钟前
小学生的练习簿完成签到,获得积分0
2分钟前
kmzzy完成签到,获得积分10
3分钟前
3分钟前
獭兔发布了新的文献求助10
3分钟前
Jasper应助科研通管家采纳,获得10
3分钟前
Hello应助科研通管家采纳,获得10
3分钟前
獭兔完成签到,获得积分10
3分钟前
4分钟前
wqc2060完成签到,获得积分10
4分钟前
FIN发布了新的文献求助50
4分钟前
sailingluwl完成签到,获得积分10
5分钟前
5分钟前
共享精神应助科研通管家采纳,获得10
5分钟前
慕青应助科研通管家采纳,获得10
5分钟前
Ava应助科研通管家采纳,获得10
5分钟前
小余同学完成签到,获得积分10
5分钟前
小余同学发布了新的文献求助10
5分钟前
CipherSage应助吴彦祖采纳,获得10
6分钟前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
Immigrant Incorporation in East Asian Democracies 600
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3968504
求助须知:如何正确求助?哪些是违规求助? 3513278
关于积分的说明 11167234
捐赠科研通 3248678
什么是DOI,文献DOI怎么找? 1794386
邀请新用户注册赠送积分活动 875030
科研通“疑难数据库(出版商)”最低求助积分说明 804638