葡萄糖摄取
化学
葡萄糖稳态
甘油三酯
内科学
胰岛素
活力测定
人参
细胞内
内分泌学
3T3-L1
蛋白激酶A
胰岛素抵抗
脂肪生成
激酶
细胞
生物化学
生物
体外
医学
胆固醇
替代医学
病理
作者
Sunmin Park,Il Sung Ahn,Dae Young Kwon,Byoung‐Seob Ko,Won Kyung JUN
摘要
Ginseng root is known to induce anti-diabetic activity, but the key components involved are unknown. We investigated which major ginsenosides in ginseng enhanced glucose homeostasis by in vitro studies. Rb1 and Rg1 reduced the triglyceride accumulation in 3T3-L1 adipocytes by activating PKA with increased intracellular cAMP. However, the insulin-stimulated glucose uptake was enhanced by Rb1 and Rg1 via activation of phosphatidylinositol-3 kinase. Rb1 and Rg1 promoted glucose-stimulated insulin secretion and cell viability in Min6 cells through PKA which augmented IRS2 expression to enhance insulin/IGF-1 signaling. These results suggest that Rb1 and Rg1 improved glucose homeostasis through the activation of a PKA like glucagon-like peptide-1 receptor agonist.
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