前哨淋巴结
医学
黑色素瘤
免疫
免疫系统
免疫学
淋巴结
癌症
活检
乳腺癌
癌症研究
病理
内科学
作者
Ryungsa Kim,Manabu Emi,Kazuaki Tanabe,Koji Arihiro
出处
期刊:Lancet Oncology
[Elsevier]
日期:2006-12-01
卷期号:7 (12): 1006-1016
被引量:52
标识
DOI:10.1016/s1470-2045(06)70975-5
摘要
The sentinel lymph node (SLN) is thought to be an important lymphoid organ for protecting against metastasis and is thought to play a crucial part in provoking antitumour immunity. Because SLN biopsy is undertaken for various types of cancers, such as malignant melanoma and breast cancer, SLN mapping has become a standard procedure, thereby eliminating unnecessary lymph-node resection in patients who do not have affected nodes. The immune surveillance activities of the SLN in melanoma and breast cancer are thought to be suppressed, whereas in cancers of gastrointestinal-tract, the presence of T cells in the SLN has not been shown to suppress the host's immune function. Furthermore, cell death after primary systemic chemotherapy for solid tumours can provoke an antigen-specific immunity in the tumour, which affects tumour response to treatment and, therefore, survival in patients. This review discusses the immunobiology of the SLN and potential strategies for activation of antitumour immunity by primary systemic chemotherapy and other modalities, in terms of tumour-size reduction and survival benefit.
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