肝细胞癌
薄壁组织
肝硬化
病理
纤维化
六氯环己烷
癌变
医学
肝实质
肿瘤进展
内科学
癌症
作者
Takashi Maeda,Mitsuo Shimada,Norifumi Harimoto,Eiji Tsujita,Shunsuke Maehara,Tatsuya Rikimaru,Shinji Tanaka,Ken Shirabe,Yoshihiko Maehara
出处
期刊:PubMed
日期:2005-03-24
卷期号:52 (61): 187-90
被引量:9
摘要
The role of trace elements in liver fibrosis, carcinogenesis and progression of hepatocellular carcinoma (HCC) has not yet been clarified. The aim of this study is to analyze the characteristics of trace elements in liver cancers and non-cancerous liver and to discuss their role in hepatic fibrosis, hepatocarcinogenesis and progression of HCC.The amount of zinc (Zn), iron (Fe), and copper (Cu) in 20 HCCs, 2 cholangiocellular carcinomas (CCC), 7 metastatic liver cancers (Meta) and their non-tumorous liver parenchyma were measured using an atomic absorption spectrophotometer.The amounts of Zn and Fe in non-tumorous liver parenchyma were reduced by liver fibrosis, and the amounts were lower in HCC tissue compared to non-tumorous liver parenchyma. The amounts of Zn and Cu were higher in HCC than the amounts found in CCC and Meta. The amount of Zn in HCC tissue decreased, but the amount of Fe increased in tumors more than 4cm in diameter.These results suggest that the decrease in the amount of Zn and Fe found in non-tumorous liver parenchyma correlates with liver fibrosis leading to cirrhosis and hepatocarcinogenesis. Also that decreases in Zn and increases of Fe in HCC tissue correlates with HCC tumor progression.
科研通智能强力驱动
Strongly Powered by AbleSci AI