医学
缺血
再灌注损伤
肺
薄壁组织
血流
活性氧
麻醉
药理学
心脏病学
内科学
病理
生物
生物化学
作者
Paul D. Weyker,Christopher Webb,David Kiamanesh,Brigid C. Flynn
标识
DOI:10.1177/1089253212458329
摘要
Lung ischemia reperfusion injury (LIRI) is a pathologic process occurring when oxygen supply to the lung has been compromised followed by a period of reperfusion. The disruption of oxygen supply can occur either via limited blood flow or decreased ventilation termed anoxic ischemia and ventilated ischemia, respectively. When reperfusion occurs, blood flow and oxygen are reintroduced to the ischemic lung parenchyma, facilitating a toxic environment through the creation of reactive oxygen species, activation of the immune and coagulation systems, endothelial dysfunction, and apoptotic cell death. This review will focus on the mechanisms of LIRI, the current supportive treatments used, and the many therapies currently under research for prevention and treatment of LIRI.
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