计算机科学
灵活性(工程)
吞吐量
软件
灵敏度(控制系统)
索引(排版)
动态规划
计算机硬件
算法
并行计算
程序设计语言
操作系统
数学
统计
工程类
无线
电子工程
作者
Ben Langmead,Steven L. Salzberg
出处
期刊:Nature Methods
[Springer Nature]
日期:2012-03-04
卷期号:9 (4): 357-359
被引量:44956
摘要
The Bowtie 2 software achieves fast, sensitive, accurate and memory-efficient gapped alignment of sequencing reads using the full-text minute index and hardware-accelerated dynamic programming algorithms. As the rate of sequencing increases, greater throughput is demanded from read aligners. The full-text minute index is often used to make alignment very fast and memory-efficient, but the approach is ill-suited to finding longer, gapped alignments. Bowtie 2 combines the strengths of the full-text minute index with the flexibility and speed of hardware-accelerated dynamic programming algorithms to achieve a combination of high speed, sensitivity and accuracy.
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