毛细血管扩张
医学
ACVRL1型
突变
基因
外显子
动静脉畸形
遗传学
内皮糖蛋白
遗传连锁
癌症研究
病理
生物
川地34
干细胞
放射科
作者
Wei Lin,Jer Yuarn Wu,Hsiu Bao Hsu,Fuu Jen Tsai,Cheng Chung Lee,Chang Hai Tsai
出处
期刊:PubMed
日期:2001-12-01
卷期号:100 (12): 817-9
被引量:22
摘要
Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant disorder characterized by multisystemic vascular dysplasia. Two related genes, endoglin and activin receptor-like kinase (ALK-1), have been mapped to chromosomes 9q34 and 12q13, respectively. We describe a Taiwanese HHT family with hepatic arteriovenous malformation. Clinical and molecular evaluations were performed in eight members of this family, and HHT symptoms were found in three adults. Short tandem repeat markers were used to perform linkage analysis, and this family was classified as HHT type 2 (ALK-1 gene). The exons of ALK-1 were amplified using the polymerase chain reaction and subjected to direct DNA sequencing. The mutation causing the disease was located at ALK-1 codon 411, causing an arginine to glutamine substitution. Five members of this family carried the mutated ALK-1 gene. This investigation successfully used linkage and sequencing techniques to perform molecular diagnosis of HHT.
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