Serial changes in levels of IL‐6 and IL‐1β in premature infants at risk for bronchopulmonary dysplasia*

支气管肺发育不良 医学 胎龄 呼吸窘迫 逻辑回归 表面活性剂疗法 出生体重 持续气道正压 胃肠病学 内科学 儿科 呼吸系统 新生儿呼吸窘迫综合征 麻醉 怀孕 阻塞性睡眠呼吸暂停 生物 遗传学
作者
S. Nadya J. Kazzi,Roberto Romero,Kathleen McLaughlin,Joel W. Ager,James Janisse
出处
期刊:Pediatric Pulmonology [Wiley]
卷期号:31 (3): 220-226 被引量:29
标识
DOI:10.1002/ppul.1032
摘要

The aim of this study was to define the inflammatory changes occurring in the lungs of infants at risk for bronchopulmonary dysplasia (BPD) over the first 28 days of life, and to define an optimal strategy for steroids therapy in the prevention of BPD. We measured levels of interleukin-6 (IL-6) and interleukin-1 beta (IL-1beta) in tracheal aspirate (TA) samples and blood of premature infants with severe respiratory distress syndrome RDS (n = 45) on the first day of life prior to initiation of surfactant therapy and on days 5-7, 12-14, 19-21, and 26-28. Levels of IL-6 and IL-1beta were determined with a commercially available enzyme-linked immunoassay. Logistic regression analyses were performed in order to examine differences in trends in levels of IL-6 and IL-1beta between groups of infants. Infants were divided into group I (n = 30, FiO(2) < or = 0.35 at 28 days) and group II (n = 15, FiO(2) > 0.35 based on their likelihood of developing BPD at 36 weeks postconceptional age (PCA). The infants were comparable with respect to mean ( +/- SEM) birth weight (895 +/- 33 g vs. 900 +/- 40 g), gestational age (27 +/- 0.38 weeks vs. 27 +/- 0.54 weeks), and severity of respiratory illness at entry into the study (mean airway pressure: 12 +/- 1 cmH(2)O vs. 12 +/- 1 cmH(2)O, and oxygen index: 15 +/- 2 vs. 19 +/- 4) (group I vs. group II, respectively). Logistic regression analyses failed to reveal any significant differences in linear trends of levels of IL-6 and IL-1beta in TA samples between both groups of infants. No particular pattern of change in levels of IL-6 or IL-1beta could be identified among groups of infants. Levels of IL-6 and IL-1beta in TA samples on the first day of life failed to predict the need for FiO(2) > 0.35 at 28 days of age. We could not identify an increasing trend or a specific pattern of changes in postnatal levels of IL-6 or IL-1beta in TA samples of infants who were at greater risk of developing BPD at 36 weeks PCA compared to infants who were not.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
2秒前
4秒前
水溶c100发布了新的文献求助10
6秒前
ren关注了科研通微信公众号
7秒前
Ava应助Stardust采纳,获得10
8秒前
桐桐应助十九岁的时差采纳,获得10
8秒前
8秒前
9秒前
研究生完成签到,获得积分10
9秒前
自觉的凛发布了新的文献求助10
10秒前
所所应助开灯人和关灯人采纳,获得10
10秒前
讨厌科研发布了新的文献求助10
11秒前
快乐一江发布了新的文献求助10
11秒前
13秒前
Tianling完成签到,获得积分0
14秒前
好吃鱼完成签到,获得积分10
14秒前
等一个晴天完成签到,获得积分10
17秒前
胡涂涂发布了新的文献求助10
19秒前
研友_VZG7GZ应助小赞采纳,获得10
20秒前
量子星尘发布了新的文献求助10
21秒前
快乐一江完成签到,获得积分10
23秒前
24秒前
29秒前
啊标完成签到,获得积分10
29秒前
29秒前
水溶c100完成签到,获得积分10
30秒前
梨江鱼完成签到,获得积分10
30秒前
LcnTCM完成签到,获得积分10
30秒前
33秒前
maizhenpeng发布了新的文献求助10
34秒前
执着乐双发布了新的文献求助30
36秒前
小赞发布了新的文献求助10
36秒前
40秒前
44秒前
沈静完成签到,获得积分10
44秒前
46秒前
loski发布了新的文献求助10
46秒前
marina完成签到 ,获得积分20
47秒前
50秒前
时尚俊驰发布了新的文献求助10
50秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989378
求助须知:如何正确求助?哪些是违规求助? 3531442
关于积分的说明 11254002
捐赠科研通 3270126
什么是DOI,文献DOI怎么找? 1804887
邀请新用户注册赠送积分活动 882087
科研通“疑难数据库(出版商)”最低求助积分说明 809173