氧化苦参碱
苦参
医学
药理学
内向整流钾离子通道
钾通道
内科学
电生理学
心脏病学
钾通道阻滞剂
离子通道
受体
苦参碱
精神科
作者
Yonggang Cao,Jing Shan,Lei Li,Jingquan Gao,Shen Zhi‐ying,Yan Liu,Xing Yan,Mingli Wu,Wang Ye,Changqing Xu,Hongli Sun
摘要
Abstract Accumulating evidence indicates that oxymatrine may exert protective effects on the cardiovascular system. This study was designed to evaluate the antiarrhythmic effects as well as the electrophysiological properties of oxymatrine. The antiarrhythmic activity of oxymatrine was observed in a rat model of arrhythmia induced by coronary ligation. Action potential duration (APD), L‐type calcium current (I Ca‐L ), transient outward potassium current (I to ) and inward rectifier potassium current (I K1 ) in rat ventricular myocytes were recorded by utilizing the whole cell patch‐clamp technique. The results showed that administration of oxymatrine significantly delayed the onset of ventricular arrhythmia, decreased the duration of ventricular arrhythmia and reduced the arrhythmia score of arrhythmic rats. The beneficial effects of oxymatrine may be related to the shortening of APD through reduction of I Ca‐L , enhancement of I to and inhibition of I K1 . Copyright © 2010 John Wiley & Sons, Ltd.
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