Apoptosis as a Therapeutic Tool in IBD?

细胞凋亡 计算生物学 医学 癌症研究 生物 遗传学
作者
Andreas Lügering,Pia Lebiedz,Stefan Koch,Torsten Kucharzik
出处
期刊:Annals of the New York Academy of Sciences [Wiley]
卷期号:1072 (1): 62-77 被引量:51
标识
DOI:10.1196/annals.1326.013
摘要

Abstract: Defective apoptosis of mucosal cell populations seems to be a relevant pathogenetic mechanism in inflammatory bowel disease (IBD). It has been suggested that the induction of apoptosis in various effector cells may be a relevant therapeutic mechanism in IBD. Indeed, it was shown that different drugs used for treatment of IBD have the capacity to induce apoptosis in T cells or monocytes in vitro and in vivo . However, it remains unclear whether these observations are related to clinical efficacy of these agents. TNF‐α is one of the most relevant proinflammatory mediators in IBD and anti‐TNF treatment has been shown to be of particular benefit for patients with IBD. It could subsequently be shown that various anti‐TNF‐α agents, such as infliximab and adalimumab, can induce apoptosis in activated monocytes and lymphocytes in vitro and in vivo . This mechanism requires reverse signaling via transmembranous TNF, thereby eliciting a signal transduction cascade that results in programmed cell death. Although other mechanisms might also contribute to the clinical effect of anti‐TNF‐α, current data suggest that apoptosis is a relevant mechanism that is associated with clinical efficacy of anti‐TNF agents. Induction of apoptosis in activated monocytes or T cells may be regarded as therapeutic tool not only for anti‐TNF agents, but also for other drugs used in IBD. Future strategies should focus on identification of mechanisms that prevent apoptosis in the mucosa of patients with IBD and in targeting apoptotic pathways as a therapeutic strategy in IBD.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
聪明水之完成签到,获得积分10
1秒前
Xiaoqiu完成签到 ,获得积分10
1秒前
外向访卉发布了新的文献求助10
1秒前
所所应助木木彡采纳,获得10
2秒前
4秒前
顺顺尼发布了新的文献求助10
4秒前
忐忑的鞅发布了新的文献求助10
6秒前
6秒前
英姑应助orz采纳,获得10
6秒前
7秒前
10秒前
董冬咚发布了新的文献求助10
10秒前
11秒前
茸茸茸发布了新的文献求助10
13秒前
科研通AI2S应助左肩微笑采纳,获得10
13秒前
14秒前
14秒前
wl1700发布了新的文献求助10
15秒前
瘦瘦的枫叶完成签到 ,获得积分10
15秒前
15秒前
16秒前
liuzhanyu发布了新的文献求助10
17秒前
17秒前
晓湫发布了新的文献求助10
18秒前
茸茸茸完成签到,获得积分10
18秒前
19秒前
琲珂发布了新的文献求助10
19秒前
20秒前
白樱恋曲发布了新的文献求助10
20秒前
21秒前
今后应助但愿人长久采纳,获得10
21秒前
你你你发布了新的文献求助10
22秒前
iu发布了新的文献求助10
22秒前
可爱的小桃完成签到,获得积分10
23秒前
hh发布了新的文献求助10
23秒前
24秒前
莫小烦完成签到,获得积分10
26秒前
忐忑的鞅完成签到,获得积分10
27秒前
28秒前
BlingBling完成签到,获得积分10
28秒前
高分求助中
The Mother of All Tableaux Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 2400
Ophthalmic Equipment Market by Devices(surgical: vitreorentinal,IOLs,OVDs,contact lens,RGP lens,backflush,diagnostic&monitoring:OCT,actorefractor,keratometer,tonometer,ophthalmoscpe,OVD), End User,Buying Criteria-Global Forecast to2029 2000
Optimal Transport: A Comprehensive Introduction to Modeling, Analysis, Simulation, Applications 800
Official Methods of Analysis of AOAC INTERNATIONAL 600
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 588
T/CIET 1202-2025 可吸收再生氧化纤维素止血材料 500
Comparison of adverse drug reactions of heparin and its derivates in the European Economic Area based on data from EudraVigilance between 2017 and 2021 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3953141
求助须知:如何正确求助?哪些是违规求助? 3498499
关于积分的说明 11092224
捐赠科研通 3229097
什么是DOI,文献DOI怎么找? 1785211
邀请新用户注册赠送积分活动 869255
科研通“疑难数据库(出版商)”最低求助积分说明 801415