抗氧化剂
超氧化物歧化酶
化学
过氧化氢酶
活性氧
NADPH氧化酶
药理学
一氧化氮
生物化学
一氧化氮合酶
酶
生物
有机化学
作者
Bruno da Cruz Pádua,Joamyr Victor Rossoni Júnior,Cintia Lopes de Brito Magalhães,Janaina Brandao Seiberf,Carolina Morais Araujo,Gustavo Henrique Bianco de Souza,Míriam Martins Chaves,Marcelo Eustáquio Silva,Maria Lúcia Pedrosa,Daniela Caldeira Costa
出处
期刊:Current Pharmaceutical Biotechnology
[Bentham Science]
日期:2014-01-31
卷期号:14 (11): 975-984
被引量:14
标识
DOI:10.2174/1389201014666131226151728
摘要
Acetaminophen is a common analgesic and antipyretic compound which, when administered in high doses, has been associated with significant morbidity and mortality, secondary to hepatic toxicity. Although this may be due to a direct interaction of reactive acetaminophen metabolites with hepatocyte proteins, recent studies have suggested that reactive species produced by neutrophils also contribute to the pathophysiological process. Researches on the chemical composition of B. trimera show that this plant has bioactive compounds such as flavonoids, related to the organism's protection against free radicals. Therefore, in the present study, using Fischer rats, the effect of B. trimera on the antioxidant defense system, the production of nitric oxide (NO) and on the expression of nitric oxide synthase (iNOS), superoxide dismutase (SOD), catalase (CAT) and of the subunits of the NADPH oxidase in neutrophils was evaluated in a model of phagocytosis induced by zimosan (ZC3b) and in a model of inflammation induced by acetaminophen. The results show that the treatment with B. trimera improves the defense system of antioxidant and restores the balance ROS / NO that is altered in the inflammatory process induced by APAP. In conclusion, B. trimera extracts exert antioxidant properties by scavenging ROS and decrease the expression of genes responsible by reactive species production in neutrophils.
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