生存素
跑
下调和上调
细胞周期蛋白D1
细胞周期
细胞周期蛋白E1
细胞周期蛋白
周期素
癌症研究
细胞周期蛋白D
细胞生物学
细胞周期蛋白
细胞生长
细胞周期蛋白B
生物
细胞周期检查点
细胞周期蛋白依赖激酶2
细胞凋亡
生物化学
基因
作者
Linhong Deng,Yuanyuan Lu,Xiaodi Zhao,Yi Sun,Yongquan Shi,Hongwei Fan,Changhao Liu,Jinfeng Zhou,Yongzhan Nie,Kaichun Wu,Daiming Fan,Xuegang Guo
标识
DOI:10.1016/j.bbrc.2013.09.079
摘要
Ran, a member of the Ras GTPase family, has important roles in nucleocytoplasmic transport. Herein, we detected Ran expression in pancreatic cancer and explored its potential role on tumour progression. Overexpressed Ran in pancreatic cancer tissues was found highly correlated with the histological grade. Downregulation of Ran led to significant suppression of cell proliferation, cell cycle arrest at the G1/S phase and induction of apoptosis. In vivo studies also validated that result. Further studies revealed that those effects were at least partly mediated by the downregulation of Cyclin A, Cyclin D1, Cyclin E, CDK2, CDK4, phospho-Rb and Survivin proteins and up regulation of cleaved Caspase-3.
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