Ultrabright Organic Dots with Aggregation‐Induced Emission Characteristics for Real‐Time Two‐Photon Intravital Vasculature Imaging

Advanced MaterialsVolume 25, Issue 42 p. 6083-6088 Communication Ultrabright Organic Dots with Aggregation-Induced Emission Characteristics for Real-Time Two-Photon Intravital Vasculature Imaging Dan Ding, Dan Ding Department of Chemical and Biomolecular Engineering, National University of Singapore, 117576 Singapore These authors contributed equally to this work.Search for more papers by this authorChi Ching Goh, Chi Ching Goh Singapore Immunology Network (SIgN), A*STAR (Agency for Science Technology and Research), Biopolis, 138648 Singapore These authors contributed equally to this work.Search for more papers by this authorGuangxue Feng, Guangxue Feng Department of Chemical and Biomolecular Engineering, National University of Singapore, 117576 SingaporeSearch for more papers by this authorZujin Zhao, Zujin Zhao Department of Chemistry and Division of Biomedical Engineering, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, ChinaSearch for more papers by this authorJie Liu, Jie Liu Department of Chemical and Biomolecular Engineering, National University of Singapore, 117576 SingaporeSearch for more papers by this authorRongrong Liu, Rongrong Liu Institute of Materials Research Engineering, 3 Research Link, 117602 SingaporeSearch for more papers by this authorNikodem Tomczak, Nikodem Tomczak Institute of Materials Research Engineering, 3 Research Link, 117602 SingaporeSearch for more papers by this authorJunlong Geng, Junlong Geng Department of Chemical and Biomolecular Engineering, National University of Singapore, 117576 SingaporeSearch for more papers by this authorBen Zhong Tang, Ben Zhong Tang Department of Chemistry and Division of Biomedical Engineering, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, ChinaSearch for more papers by this authorLai Guan Ng, Corresponding Author Lai Guan Ng Singapore Immunology Network (SIgN), A*STAR (Agency for Science Technology and Research), Biopolis, 138648 SingaporeE-mail: [email protected], [email protected]Search for more papers by this authorBin Liu, Corresponding Author Bin Liu Department of Chemical and Biomolecular Engineering, National University of Singapore, 117576 Singapore Institute of Materials Research Engineering, 3 Research Link, 117602 SingaporeE-mail: [email protected], [email protected]Search for more papers by this author Dan Ding, Dan Ding Department of Chemical and Biomolecular Engineering, National University of Singapore, 117576 Singapore These authors contributed equally to this work.Search for more papers by this authorChi Ching Goh, Chi Ching Goh Singapore Immunology Network (SIgN), A*STAR (Agency for Science Technology and Research), Biopolis, 138648 Singapore These authors contributed equally to this work.Search for more papers by this authorGuangxue Feng, Guangxue Feng Department of Chemical and Biomolecular Engineering, National University of Singapore, 117576 SingaporeSearch for more papers by this authorZujin Zhao, Zujin Zhao Department of Chemistry and Division of Biomedical Engineering, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, ChinaSearch for more papers by this authorJie Liu, Jie Liu Department of Chemical and Biomolecular Engineering, National University of Singapore, 117576 SingaporeSearch for more papers by this authorRongrong Liu, Rongrong Liu Institute of Materials Research Engineering, 3 Research Link, 117602 SingaporeSearch for more papers by this authorNikodem Tomczak, Nikodem Tomczak Institute of Materials Research Engineering, 3 Research Link, 117602 SingaporeSearch for more papers by this authorJunlong Geng, Junlong Geng Department of Chemical and Biomolecular Engineering, National University of Singapore, 117576 SingaporeSearch for more papers by this authorBen Zhong Tang, Ben Zhong Tang Department of Chemistry and Division of Biomedical Engineering, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, ChinaSearch for more papers by this authorLai Guan Ng, Corresponding Author Lai Guan Ng Singapore Immunology Network (SIgN), A*STAR (Agency for Science Technology and Research), Biopolis, 138648 SingaporeE-mail: [email protected], [email protected]Search for more papers by this authorBin Liu, Corresponding Author Bin Liu Department of Chemical and Biomolecular Engineering, National University of Singapore, 117576 Singapore Institute of Materials Research Engineering, 3 Research Link, 117602 SingaporeE-mail: [email protected], [email protected]Search for more papers by this author First published: 19 August 2013 https://doi.org/10.1002/adma.201301938Citations: 248 Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley 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Learn more.Copy URL Graphical Abstract Ultrabright organic dots with aggregation-induced emission characteristics (AIE dots) are prepared and shown to exhibit a high quantum yield, a, large two-photon absorption cross-section, and low in vivo toxicity. Real-time two-photon intravital blood vascular imaging in various tissues substantiates that the AIE dots are effective probes for in vivo vasculature imaging in a deep and high-contrast manner. References 1a) R. N. Germain, M. J. Miller, M. L. Dustin, M. C. Nussenzweig, Nat. Rev. Immunol. 2006, 6, 497; b) J. L. Y. Li, C. C. Goh, J. L. Keeble, J. S. Qin, B. Roediger, R. Jain, Y. Wang, W. K. Chew, W. Weninger, L. G. Ng, Nat. Protocols 2012, 7, 221. 2a) D. R. Larson, W. R. Zipfel, R. M. Williams, S. W. Clark, M. P. Bruchez, F. W. Wise, W. W. Webb, Science 2003, 300, 1434; b) K. Schenke-Layland, I. Riemann, O. Damour, U. A. Stock, K. Konig, Adv. Drug Delivery Rev. 2006, 58, 878. 3a) J. V. Frangioni, Curr. Opin. Chem. 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